For the 3rd GCOM conference, we have selected five highly interesting topics, which cover various aspects of myositis and associated fields.
(Juvenile) dermatomyositis; (j)DM
Dermatomyositis can affect children and adults. The prognosis and therapy options as well as pathomechanisms differ significantly between children and adults. The presence of autoantibodies is of special interest and their physiopathological significance is beginning to be explored. Therefore, we want to focus on differences and similarities between children and adults with DM.
Sporadic inclusion body myositis; IBM
Over the years, a broad range of new insights in terms of pathophysiology, therapy and genetics was found and led to new research options. We may learn from genetically defined diseases harboring similar morphological features as the ‘sporadic’ form of IBM. The state of the art on sIBM will be presented and future avenues will be explored.
Immune-mediated necrotizing myopathies; IMNM
Definition of morphology, clinical aspects and relevance of the autoantibodies anti-SRP and anti-HMGCR of patients within this newly defined group was published recently. To account for this development, new concepts and therapy options will be discussed and presented. The role of macrophage subtypes is addressed more specifically.
Extra-muscular aspects in myositis
Not only the affection of skeletal muscle is a hallmark of myositis, some diseases may feature considerable involvement of other organs, like the lung or skin. These additional affections might be of outmost importance during the disease course. Cancer is certainly the most relevant associated disease in adult myositis, and we will shed light on underlying mechanisms.
Treatment options in myositis
All research is conducted with the goal to understand the disease and treat the patients. Since myositis is a rare disease, big cohort studies are largely lacking, and treatment options are often insufficient. However, development of new concepts and drugs is expanding and late-breaking developments will be covered in this session.